Sentinel Monitoring
How Sentinel keeps your results current as genomic science advances
6 min read
How Sentinel Works
Your DNA doesn't change, but scientific understanding does. Every month, thousands of new research papers are published that can change how we interpret genetic variants. Sentinel automatically re-analyzes your genome against the latest databases and research.
Monthly Re-Scanning
Every month, we run your VCF file through our classification engine using the latest ClinVar, gnomAD, and proprietary database updates. This happens automatically - no action needed.
Reclassification Detection
If a variant's classification changes (e.g., VUS upgraded to Pathogenic based on new evidence), we flag it immediately and notify you.
Smart Notifications
We only notify you about changes that matter - not every database update. You'll get alerts for reclassifications, new research on your variants, and important health updates.
Sentinel Plans
Every Humanome test includes free Sentinel monitoring to get you started:
Sentinel Monitoring
$7.99/mo- • Monthly genome re-scanning
- • Reclassification alerts
- • New research notifications
- • Email alerts
Sentinel Plus
Recommended- • Everything in Monitoring, plus:
- • AI-powered variant summaries
- • Clinical trial matching
- • Priority re-scanning
- • Ancestry insights
- • Carrier status updates
Save with Annual Plans: Pay yearly and save up to 17% - plus get priority support!
Notification Settings
Customize how and when you receive Sentinel alerts:
Reclassification Alerts
When a variant's classification changes
New Research
When relevant papers are published
Monthly Scan Summary
Monthly digest of your scan status
Manage these settings from Dashboard → Settings → Notifications