Understanding Your Results
A guide to reading and interpreting your DNA analysis results
8 min read
What Are Genetic Variants?
Your DNA is made up of about 3 billion "letters" (called base pairs). A variantis simply a spot where your DNA differs from the reference human genome. Most variants are completely harmless - they're what makes you unique. However, some variants can affect your health.
Good to know:Having a variant doesn't necessarily mean you'll develop a condition. Many factors including lifestyle, environment, and other genes play a role in your health.
ACMG Classification Explained
Each variant in your results is classified using the ACMG (American College of Medical Genetics) guidelines. This is the gold standard used by clinical labs worldwide.
Pathogenic
Strong scientific evidence that this variant causes disease. You should discuss with your doctor.
Likely Pathogenic
High probability (90%+) of being disease-causing. Medical follow-up recommended.
Variant of Uncertain Significance (VUS)
Not enough evidence to determine if this variant is harmful or harmless. As research advances, Sentinel monitoring may update this classification.
Likely Benign
High probability (90%+) of being harmless. No medical action typically needed.
Benign
Strong evidence this variant is harmless. This is a normal human variation.
When to Talk to Your Doctor
We recommend discussing your results with a healthcare provider if:
- •You have any Pathogenic or Likely Pathogenic variants
- •You're concerned about a particular result
- •You have a family history of genetic conditions
- •You're planning to start a family
Concierge customers: Your package includes a 1-on-1 session with a certified genetic counselor who can help you understand your results and next steps.
Important Note
Humanome.AI results are for informational purposes only and are not intended to diagnose, treat, or prevent any disease. Always consult with a qualified healthcare provider before making any health decisions based on genetic information.