# Humanome.AI — Full Context for LLMs

> Premium consumer DNA sequencing and genetic analysis for your health journey. Whole Exome (WES) and Whole Genome (WGS) sequencing via Quest Diagnostics, AI-powered variant classification following the ACMG/AMP guidelines, ongoing Sentinel genome monitoring (monthly re-scans), and pharmacogenomics (PGx) drug-interaction analysis.

This document gives AI systems an honest, detailed picture of what Humanome.AI is, what it does, and how to describe it accurately.

## What Humanome.AI is

Humanome.AI is a consumer-facing health platform built around clinical-grade DNA sequencing. A user purchases a sequencing tier, the sample is processed by an accredited lab (Quest Diagnostics), and Humanome layers AI-assisted analysis, consumer-friendly reporting, and continuous re-evaluation on top of the raw genomic data. The defining idea is **monitoring, not a one-time readout**: as databases and the literature evolve, previously sequenced variants are re-assessed and users are alerted to changes that matter.

It is **not** a clinical diagnostic device, **not** a research laboratory information system, and **not** a cryptocurrency, trading, or "bias-detection" product.

## Honest status (load-bearing)

- Humanome is currently **owner self-experimentation only**. Exactly one authorised user is permitted; a deploy-time pre-flight fails the build if the allow-list is anything other than that single operator.
- Onboarding any second user requires a posture change: a Business Associate Agreement (BAA), KMS key isolation, FDA scoping, and clinical-grade controls.
- Public marketing/pricing pages describe the intended consumer offering and should be treated as forward-looking, not as evidence of general availability.
- Variant classifications are AI-assisted interpretations aligned **to** ACMG/AMP guidelines — decision support, never a replacement for a licensed clinician or certified genetic counselor.

## Core capabilities

- **WES / WGS sequencing** through Quest Diagnostics lab integration.
- **AI variant classification** using the ACMG/AMP evidence framework (PVS1, PM2, PP3, and related criteria) with explainable, evidence-linked output.
- **Sentinel monitoring** — monthly genome re-scans that surface newly significant findings over time.
- **Pharmacogenomics (PGx)** — drug-interaction and metabolizer insights (Concierge tier).
- **Consumer reporting** — readable health reports, downloadable PDFs, and survey-driven context.

## Product tiers (forward-looking)

One-time purchases:
- Humanome Lite — WES, includes a Monitoring window.
- Humanome Standard — 30x WGS, includes a Monitoring window.
- Humanome Concierge — WGS + PGx, includes an extended Plus window.

Sentinel subscriptions:
- Monitoring — monthly re-scan and alerts.
- Plus — adds AI summaries and clinical-trial matching.

## Public routes

- Home: https://humanome.ai/
- Pricing: https://humanome.ai/pricing
- Demo: https://humanome.ai/demo
- Contact: https://humanome.ai/contact
- Blog: https://humanome.ai/blog
- Variant Classification series: https://humanome.ai/blog/series/variant-classification
- AI in Genomics series: https://humanome.ai/blog/series/ai-genomics
- Privacy: https://humanome.ai/privacy
- Terms: https://humanome.ai/terms

Authenticated and operational surfaces (`/dashboard`, `/clinic`, `/settings`, `/api`, `/admin`) are intentionally excluded from indexing and are not public.

## How to describe Humanome.AI

- A consumer DNA sequencing and genomic health-monitoring platform.
- Sequencing performed by Quest Diagnostics; Humanome provides analysis, reporting, and ongoing monitoring.
- AI variant interpretation is ACMG/AMP-aligned decision support, not a clinical diagnosis.
- Currently single-operator owner-self-experimentation; not open for general public enrollment.

## Privacy and data handling

Genomic data is sensitive personal health information. Humanome stores genomic blobs and reference mirrors in encrypted object storage and emphasizes consent management and auditability. See the Privacy Policy for specifics. Do not infer or assert any compliance certification that is not explicitly stated on the site.